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Molecular Biology: Mechanism of Gene Silencing

Learn about mechanisms of gene silencing and their role in plant growth and development
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Platform: Udemy
Video: 1h 23m
Language: English
Next start: On Demand

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9.1 / 10

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This course was last updated on 4/2022.

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7.7 / 10
Video Score: 7.8 / 10
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Detail Score: 9.8 / 10

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Table of contents

Description

There are around 30-40 trillion cells in the human body. Each cell consists of an outer membrane, cytoplasm, and nucleus, which controls the activity of the rest of the cell. DNA (deoxyribonucleic acid), which contains the ‘genetic code’ of living things, is located in the nucleus. DNA remains confined to the nucleus of the cell and it relies on another molecule, RNA, to deliver its instructions and translate them into action. When the instructions are turned into a functional product, such as a protein, this is called gene expression.
Gene silencing is generally defined as an epigenetic modification of gene expression leading to inactivation of previously active individual genes. Gene silencing makes use of the body’s natural processes to control disease by suppressing or ‘silencing’ specific genes that are associated with certain diseases. In this context, ‘silencing’ means temporarily blocking a specific gene’s message that would otherwise trigger an unwanted effect. It is considered a gene knockdown mechanism since the methods used to silence genes generally reduce the expression of a gene by at least 70% but do not eliminate it.
Gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS).
Transcriptional gene silencing (TGS) is a nuclear-localized mechanism, which quenches transcription by blocking a promoter region for the binding of transcriptional machinery. Different methods of TGS are RNA-directed DNA methylation (RdDM), genomic imprinting, paramutation, transposon silencing, and position effect.
Post-transcriptional gene silencing (PTGS) is a cytoplasm-localized phenomenon to precisely target and degrade mRNA transcripts of specific genes. Different methods of PTGS are RNA interference (RNAi), clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), and nonsense mediated decay (NMD).
Gene silencing plays important role in the growth and development of plants by transgene silencing, taming of TEs, detoxifing of toxins and allergens, improving quality traits and providing immunity against biotic and abiotic stress.
This course is a valuable resource for students and researchers related to biochemistry, molecular biology, biotechnology, and genetics.
Start your learning journey now and explore the hidden truth about nature!

You will learn

✓ Introduction to gene and protein
✓ What is gene silencing?
✓ Why gene silencing is needed?
✓ Difference between gene silencing and gene therapy
✓ History of gene silencing
✓ Types of gene silencing
✓ What is transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS)
✓ RNA-directed DNA methylation
✓ Genomic imprinting
✓ Paramutation
✓ Transposon silencing
✓ Position effect
✓ RNA interference (RNAi)
✓ Clustered regularly interspaced short palindromic repeats (CRISPR/Cas9)
✓ Nonsense mediated decay (NMD)
✓ Advantages and disadvantages of gene silencing
✓ Applications of gene silencing
✓ Role of gene silencing in plants

Requirements

• Motivation to learn
• Basic knowledge of biology and Biochemistry
• Interested in learning gene silencing mechanisms

This course is for

• The course is designed for researchers of biochemistry, molecular biology, and related disciplines.
• Students who wants to persude their career in biochemitsry, research, clinincal analysis and genetics.

How much does the Molecular Biology: Mechanism of Gene Silencing course cost? Is it worth it?

The course costs $14.99. And currently there is a 40% discount on the original price of the course, which was $24.99. So you save $10 if you enroll the course now.

Does the Molecular Biology: Mechanism of Gene Silencing course have a money back guarantee or refund policy?

YES, Molecular Biology: Mechanism of Gene Silencing has a 30-day money back guarantee. The 30-day refund policy is designed to allow students to study without risk.

Are there any SCHOLARSHIPS for this course?

Currently we could not find a scholarship for the Molecular Biology: Mechanism of Gene Silencing course, but there is a $10 discount from the original price ($24.99). So the current price is just $14.99.

Who is the instructor? Is Anum Ahmad, PhD a SCAM or a TRUSTED instructor?

Anum Ahmad, PhD has created 8 courses that got 51 reviews which are generally positive. Anum Ahmad, PhD has taught 854 students and received a 4.3 average review out of 51 reviews. Depending on the information available, Anum Ahmad, PhD is a TRUSTED instructor.
Educator
I am a PhD (microbiology) from a reputed university. I have been teaching biology and chemistry for more than 7 years in prestigious institutes.
Biology and chemistry are the fields that need a lot of toil and laser-sharp focused attention. These subjects could be difficult as mountain climbing and easy as watching your favorite TV serial depending on who your teacher is.
I aim to make these subjects as easy and interesting as possible. Linking these subjects to daily life is an interesting way to retain the knowledge of these subjects. Keeping these things in mind, I have designed these courses to aid the students.
I am not only a teacher but also a researcher. I worked on different aspects of life sciences including:
Biotechnology
Rumen microbiota
Animal nutrition
Molecular biology (cloning and expression of genes)
My research experience has opened a vast horizon of knowledge in front of me, which I am willing to share with my students to contribute towards their self-achievement and value addition.

9.1

CourseMarks Score®

10.0

Freshness

N/A

Feedback

7.7

Content

Platform: Udemy
Video: 1h 23m
Language: English
Next start: On Demand

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